TRANSPLANTATION Related transplantation with HLA-1 Ag mismatch in the GVH direction and HLA-8/8 allele-matched unrelated transplantation: a nationwide retrospective study
نویسندگان
چکیده
1Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan; 2Adult Stem Cell Transplant Program, Division of Cellular Therapy, Department of Medicine, Duke University Medical Center, Durham, NC; 3HLA Laboratory, Kyoto, Japan; 4Stem Cell Transplantation Division, National Cancer Center Hospital, Tokyo, Japan; 5Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, Tokyo, Japan; 6Department of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan; 7Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan; 8Department of Hematology and Oncology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan; 9Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan; 10Department of Medicine, Division of Hematology, Keio University School of Medicine, Tokyo, Japan; 11Department of Internal Medicine, National Hospital Organization, Kumamoto Medical Center, Kumamoto, Japan; 12Department of Blood Transfusion, Hiroshima Red Cross and Atomic Bomb Survivors Hospital, Hiroshima, Japan; 13Department of Internal Medicine, Toyama Prefectural Central Hospital, Toyama, Japan; 14Stem Cell Transplantation Center, Hokkaido University Hospital, Sapporo, Japan; 15Department of Haematology/Oncology, Osaka Medical Centre and Research Institute for Maternal and Child Health, Osaka, Japan; 16Department of Hematology and Cell Therapy, Aichi Cancer Center Hospital, Nagoya, Japan; and 17Department of Hematopoietic Stem Cell Transplantation Data Management/Biostatistics, Nagoya University School of Medicine, Nagoya, Japan
منابع مشابه
Related transplantation with HLA-1 Ag mismatch in the GVH direction and HLA-8/8 allele-matched unrelated transplantation: a nationwide retrospective study.
To clarify which is preferable, a related donor with an HLA-1 Ag mismatch at the HLA-A, HLA-B, or HLA-DR loci in the graft-versus-host (GVH) direction (RD/1AG-MM-GVH) or an HLA 8/8-allele (HLA-A, HLA-B, HLA-C, and HLA-DRB1)-matched unrelated donor (8/8-MUD), we evaluated 779 patients with acute leukemia, chronic myelogenous leukemia, or myelodysplastic syndrome who received a T cell-replete gra...
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Risk of relapse during the unrelated donor coordination period biases comparisons between allogeneic hematopoietic stem cell transplantation from an HLA 8 of 8 allele-matched unrelated donor (8/8 MUD) and that from a related donor with an HLA-1 antigen mismatch in the graft-versus-host (GVH) direction (RD/1AGMM-GVH). To reduce this bias, we performed a decision analysis focusing on acute myeloi...
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Allogeneic hematopoietic stem cell transplantation (HSCT) is a proven curative therapy for many hematologic malignancies. HSCT from HLA-identical sibling donors (ISDs) is still the golden standard. For the remaining 70% of the patients lacking an ISD, alternative (partially) HLA-matched family donors (MFDs) and HLA-matched unrelated donors (MUDs) are now widely accepted. However, it is presentl...
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HLA matching between donors and recipients is the most important factor associated with acute graft-versus-host disease (GVHD) following allogeneic hematopoietic stem cell transplantation. With improvements in GVHD prophylaxis and supportive care, transplantations from HLA mismatched donors are performed increasingly frequently, drawing greater attention to the effects of HLA mismatch. In relat...
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We examined current outcomes of unrelated donor allogeneic hematopoietic cell transplantation (HCT) to determine the clinical implications of donor-recipient HLA matching. Adult and pediatric patients who had first undergone myeloablative-unrelated bone marrow or peripheral blood HCT for acute myelogenous leukemia, acute lymphoblastic leukemia, chronic myelogenous leukemia, and myelodysplastic ...
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